SCIENTIFIC STUDIES:
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
http://jnci.oxfordjournals.org/content/100/1/59.abstract
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html
Inhibition of tumor angiogenesis by cannabinoids
http://www.fasebj.org/content/17/3/529.full
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
http://www.ncbi.nlm.nih.gov/pubmed/16078104?dopt=Abstract
A pilot clinical study of 9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html
Cannabinoids as potential new therapy for the treatment of gliomas
http://www.expert-reviews.com/doi/abs/10.1586/14737175.8.1.37
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
http://www.ncbi.nlm.nih.gov/pubmed/17934890?dopt=Abstract
Expression of cannabinoid receptors and neurotrophins in human gliomas
http://www.ncbi.nlm.nih.gov/pubmed/18175076?dopt=Abstract
Δ9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer Cells through Cdc2 Regulation
http://cancerres.aacrjournals.org/content/66/13/6615.abstract
Anti-tumor activity of plant cannabinoids with
emphasis on the effect of cannabidiol on human breast carcinoma
http://jpet.aspetjournals.org/content/early/2006/05/25/jpet.106.105247.full.pdf+html
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
http://jpet.aspetjournals.org/content/308/3/838.full
The endogenous cannabinoid anandamide inhibits human breast
cancer cell proliferation
http://www.pnas.org/content/95/14/8375.full.pdf+html
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
http://mct.aacrjournals.org/content/6/11/2921.abstract
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
http://www.molecular-cancer.com/content/9/1/196
Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer
http://cancerres.aacrjournals.org/content/65/5/1635.abstract
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production
http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
http://gut.bmj.com/content/54/12/1741.abstract
Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
http://bloodjournal.hematologylibrary.org/cgi/content/full/105/3/1214
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/16908594
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html
Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
http://cancerres.aacrjournals.org/content/66/13/6748.abstract
Cannabinoids in pancreatic cancer: Correlation with survival and pain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225529/
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
http://jnci.oxfordjournals.org/content/100/1/59.abstract
Cannabinoids inhibit cellular respiration of human oral cancer cells
http://www.ncbi.nlm.nih.gov/pubmed/20516734
The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration
http://www.ncbi.nlm.nih.gov/pubmed/19916793
Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/16936228
xpression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
http://onlinelibrary.wiley.com/doi/10.1002/ijc.23584/abstract
Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
http://www.ncbi.nlm.nih.gov/pubmed/20053780
Cannabinoids and Cancer
http://www.bentham.org/mrmc/contabs/mrmc5-10.htm#6
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
http://www.jci.org/articles/view/16116/version/1
http://medlibrary.org/medwiki/Glioma: (specifically section under THC – “Most Recently investigators at the University of California, Pacific Medical Center reported that cannabinoids possess synergistic anti-cancer properties — finding that the administration of a combination of the plant’s constituents is superior to the administration of isolated compounds alone.[13]”)
Cannabidiol enhances the inhibitory effects of Δ9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806496/?tool=pmcentrez
Cannabinoids and cancer
http://www.ncbi.nlm.nih.gov/pubmed/16250836
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/9771884
Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach.
http://www.ncbi.nlm.nih.gov/pubmed/18608861
Cannabinoids for Cancer Treatment: Progress and Promise
http://cancerres.aacrjournals.org/content/68/2/339.abstract :
Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non–Small Cell Lung Cancer Growth and Metastasis
http://cancerpreventionresearch.aacrjournals.org/content/4/1/65.abstract
A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
http://mct.aacrjournals.org/content/10/1/90.abstract
The Levels of the Endocannabinoid Receptor CB2 and Its Ligand 2-Arachidonoylglycerol Are Elevated in Endometrial Carcinoma
http://endo.endojournals.org/cgi/content/abstract/151/3/921
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
http://mct.aacrjournals.org/content/8/11/3117.abstract
Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
http://mcr.aacrjournals.org/content/7/7/1086.abstract
Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells
http://clincancerres.aacrjournals.org/content/14/23/7691.abstract
Breast CancerDelta(9)-tetrahydrocannabinol inhibits 17beta-estradiol-induced proliferation and fails to activate androgen and estrogen receptors in MCF7 human breast cancer cells
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/cancer/cancer.html
Colorectal Cancer
The cannabinoid 9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/cancer/colorectal_cancer.html
Lymphoma
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/cancer/lymphoma.html
Melanoma
Cannabinoid receptors as novel targets for the treatment of melanoma
http://www.uccs.edu/~rmelamed/Evolutionism/medical_uses_of_cannabinoid_2/cancer/melanoma.html
LINK TO 500+ MEDICAL ARTICLES ON PUBMED.GOV
http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&term=cannabinoid+cancer+treatment
I have said it over and over, legalizing HEMP in America ain’t gonna happen. Industrializing the growth of marijuana for medicine in America IS going to happen, and it is for a good reason.
We are growing for the medicine part of the Cannabis pie for the world. China and Northern Europe get paper and clothes, south america for fuel, North America for medicine and Africa for food. global segregation of the uses of hemp provides protection from the genetic dilution of the strains that are used for their respective industrial applications.
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It is as plain as the nose on your face if you try to find a rationale for the prohibition that goes beyond the little short sighted, greed based motivations of the “truffle-snufflers” who are in charge of making the segregation happen.
Jack herer prohesied that HEMP will run the world and what he says is TRUE! that cannot happen all in one place on the planet!!!
It is common sense…
The California Supreme Court today struck down the state’s limits on how
much medical marijuana a patient can possess, concluding that the
restrictions imposed by the Legislature were an unconstitutional
amendment of a 1996 voter-approved initiative.
The decision means that patients and caregivers with a doctor’s recommendation to use marijuana can now possess as much as is
“reasonably related to the patient’s current medical needs,” a standard
that the court established in a 1997 decision.
“I’m very pleased. They gave us exactly what we wanted,” said Gerald F. Uelmen, a law professor at Santa Clara University who argued
the case for Patrick K. Kelly, a medical marijuana patient from
Lakewood who was convicted of possession and cultivation. “This makes
it very clear that all of the rights of patients under the
Compassionate Use Act are fully preserved.”
The initiative did not limit the amount of marijuana that a patient could possess or cultivate other than to require it be
“personal medical purposes.”
Report says marijuana is used by nearly half of older drug users
An estimated 4.3 million Americans age 50 and older‹roughly one out of every 20 in that age group‹have used at least one drug illicitly within the past year, according to a government report released today that offers an intriguing snapshot of aging Americans and drugs.
Those who admitted to illicit drug use included nearly one in 10 boomers between ages 50 and 54, and one in 14 of those between 55 and 59, according to the National Survey on Drug Use and Health, which included a sample of nearly 20,000 older Americans.
Of the group that said they used drugs, marijuana was the drug of choice for nearly half of those 50 and older (44.9 percent). One-third (33.4 percent) admitted to taking prescription drugs for purposes other than their intended use. The survey was sponsored by the federal Substance Abuse and Mental Health Services Administration (SAMHSA).
The findings follow previous research from the agency, released last summer, noting that marijuana use among those in their 50s increased by 84 percent since 2002. ³For the most part, this is a group of people that, as they age, never gave it up,² Peter Delany, who directs the agency¹s research, tells Bulletin Today.
Marijuana use was more prevalent among those in their 50s than in other age groups, the new report finds, while nonmedical use of prescription drugs was more common in men and women 65 and older. ³We can¹t explain why more older adults are misusing prescription drugs,² Delany says, ³but we can say that those medications are more available than they used to be.² It may be, he says, that people with valid prescriptions are disposing of their medication improperly, or that some are sharing their medication with others.
The survey did not track the reasons for taking the drugs‹whether they were for pain or for pleasure. But, Delany adds, ³If this trend continues‹and we expect it will‹the number of those in this age group who need treatment may double this decade.²
He sees the findings as a wake-up call for health professionals to do a better job of screening older patients for signs of drug abuse or misuse. ³When I go to my physician,² Delany says, ³I¹m asked about my tobacco and alcohol use, but I¹m not asked if I¹m using drugs. Also, I¹m not asked if I¹m feeling sad or want to hurt myself.²
Looking at all age groups, researchers find that men have higher rates of all types of illicit drug use, with one exception: women between ages 60 and 64. They are nearly twice as likely as men in their age group to take prescription drugs for nonprescription purposes.
The potential for prescription misuse‹and abuse‹in older Americans is nothing new. In a 2007 study published in the American Journal of Geriatric Pharmacotherapy, researchers from the University of Maryland¹s School of Pharmacy in Baltimore found that one in four older adults had exposure to prescription medications with ³abuse potential.²
³Most are painkillers,² says Linda Simoni-Wastila, a professor and lead author of that research. ³And a lot of it starts out as appropriate. Older folks don¹t usually run out and say, ŒI¹m going to be a recreational user.¹ But they have lower back pain, they can¹t sleep, so their doctor continues to prescribe the drugs‹and they get hooked.²
She adds that she¹s not surprised by the new SAMHSA research. She theorizes that in addition to old habits‹the Woodstock generation holding on to its pot-smoking habit of yesteryear‹there is also new, growing acceptance and use of medical marijuana.
Although alcohol use was not included in the national survey, Simoni-Wastila says it should be. ³When psychoactive drugs are [used or] abused in combination with alcohol, it can cause a lot of problems. These drugs should not be used in combination with each other‹or with alcohol.²
Sid Kirchheimer writes about consumer and health issues.
(FOXNEWS) President Obama’s school age daughters have not been vaccinated against the H1N1 flu virus. White House Press Secretary Robert Gibbs says the vaccine is not available to them based on their risk.
Providence, RI: The moderate long-term use of marijuana is associated with a reduced risk of head and neck cancers, according to the results of a population-based case-control study published online by the journal Cancer Prevention Research.
Investigators at Rhode Island’s Brown University, along with researchers at Boston University, Louisiana State University, and the University of Minnesota assessed the lifetime marijuana use habits of 434 cases (patients diagnosed with head and neck squamous cell carcinoma from nine medical facilities) compared to 547 matched controls.
Authors reported, “After adjusting for potential confounders (including smoking and alcohol drinking), 10 to 20 years of marijuana use was associated with a significantly reduced risk of head and neck squamous cell carcinoma … [as was] moderate weekly use.”
Subjects who smoked marijuana and consumed alcohol and tobacco (two known high risk factors for head and neck cancers) also experienced a reduced risk of cancer, the study found.
“Our study suggests that moderate marijuana use is associated with reduced risk of HNSCC,” investigators concluded. “This association was consistent across different measures of marijuana use (marijuana use status, duration, and frequency of use). … Further, we observed that marijuana use modified the interaction between alcohol and cigarette smoking, resulting in a decreased HNSCC risk among moderate smokers and light drinkers, and attenuated risk among the heaviest smokers and drinkers. … Despite our results being consistent with the point estimates from other studies, there remains a need for this inverse association to be confirmed by further work, especially in studies with large sample sizes.”
A separate 2006 population case-control study also reported that lifetime use of cannabis was not positively associated with cancers of the lung or aerodigestive tract, and noted that certain moderate users of the drug experienced a reduced cancer risk compared to non-using controls.
By contrast, a study published earlier this week in the journal Cancer Epidemiology reports that even the moderate use of alcohol (six drinks or less per week) is associated with an elevated risk of various cancers – including stomach cancer, rectal cancer, and bladder cancer.
For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “A population-based case control study of marijuana use and head and neck squamous cell carcinoma,” will appear in Cancer Prevention Research.
Washington City Paper – With crack and marijuana stashed in his pocket, Kenneth Millard and some friends scattered when an unmarked police car rolled into the parking lot outside his apartment building in Southeast. The cops were looking for someone else, but Millard fell into the trap.
After bolting through a cut in the woods and stumbling down a steep hill, Millard bounced off the side of another police car blocking his escape route. He dodged and weaved down Jasper Road SE until two officers tackled and cuffed him on the pavement. Police said a Colt .22 handgun, loaded with 11 rounds, flew out of Millard’s waistband during the chase and landed near a manhole.
When officers caught Millard that February night in 2005, they found 10 plastic bags filled with crack cocaine and marijuana in the right front pocket of his coveralls, according to court records. Millard’s lengthy rap sheet was growing longer, and he was heading back to jail.
At his trial in 2006, the jury convicted Millard on five drug and firearm charges, and the judge sentenced him to four-and-a-half years in prison.
But he just caught a break.
The D.C. Court of Appeals has reversed all of Millard’s convictions, wiping them off his record with a unanimous decision in March.
After overturning one of its own earlier precedents, the highest court in the District has reversed convictions in at least 14 cases involving drug dealers and others caught with drugs. The reversals hinge on an important constitutional issue stemming from eight words tucked in the Sixth Amendment known as the Confrontation Clause. In all criminal prosecutions, the accused has the right “to be confronted with the witnesses against him.”
In Millard’s case, the “missing” witness was a chemist from the Drug Enforcement Administration whose drug analysis report stated that the baggies in Millard’s pocket contained cocaine and marijuana. Because the analyst didn’t appear in court, Millard’s drug convictions were reversed, but the firearm convictions were tossed out, too, because of weak evidence and their connection to the drug case.
The legal fight playing out in D.C. will be spreading across the nation after a Supreme Court decision in June in a case with striking similarities to Millard’s. The 5-4 ruling in Melendez-Diaz v. Massachusetts could result in thousands of reversed convictions and dismissed drug, drunken-driving, and other charges, creating the potential for chaos in the justice system.